化工社化工社 化学情報印刷レポート · 研究参考用
Ethanol → alpha-(Aminomethyl)-4-methoxybenzyl alcohol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Hydroxylamine | HCID 787 | — |
| 反応物 | 4-Methoxybenzaldehyde | HCID 31244 | — |
| 反応物 | Fumaric Acid | HCID 444972 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 生成物 | alpha-(Aminomethyl)-4-methoxybenzyl alcohol | HCID 3016949 | — |
反応手順
2-Amino-1-(4-methoxyphenyl)ethanol was prepared according to the procedure of Evans et al., J. Org. Chem., 39, 914 (1974) by cyanosilylation of 4-methoxybenzaldehyde followed by lithium aluminum hydride reduction. The crude aminoalcohol (36.9 g) was dissolved in 150 mL of hot ethanol on a steam bath. To this mixture was slowly added 12.83 g of fumaric acid. The precipitated salt was filtered and washed with additional ethanol. Recrystallization from methanol provided greater than 99% pure 2:1 amine:fumarate salt.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07820785B2 |
| 出典データセット | uspto-grants-2010_10 |
| ORD ID | ord-4f214d5ffe7b408ba41ae7cf9e3a8882 |
| 出典メモ | uspto-grants-2010_10 |