Hydrochloric Acid → 1-(Prop-2-en-1-yl)piperazin-2-one
反応式
[CH2:1]([N:4]1[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][C:5]1=[O:17])[CH:2]=[CH2:3].Cl>CCOC(C)=O>[CH2:1]([N:4]1[CH2:9][CH2:8][NH:7][CH2:6][C:5]1=[O:17])[CH:2]=[CH2:3]参加物
4
反応条件
- 温度
- 0 °C
実験手順
Into a stirred solution of 1-(2-propenyl)-4-tert-butyloxycarbonyl-2-piperazinone (11 g, 46 mmol) in EtOAc (100 mL) at 0° C. was bubbled HCl gas for 10 min. The mixture was stirred at 0° C. for 30 min and then at ambient temperature for 1 h. The solvent was removed in vacuo to yield the hydrochloride salt of the title compound as a white solid. ES MS (M+H)=141.
後処理
- waitat ambient temperature for 1 h
- customThe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-9300c0339c024c21ab4b2edce0e23cd6
- 出典データセット
- uspto-grants-2010_10
- 特許番号
- US07820680B2
反応ノート
読み込み中…