9-hydroxy-7-isopropyl-2-(1-propenyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,6,8(7H)-trione → 9-Hydroxy-7-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,6,8(7H)-trione
反応式
[OH:1][C:2]1[C:7](=[O:8])[N:6]([CH:9]([CH3:11])[CH3:10])[C:5](=[O:12])[N:4]2[CH2:13][CH2:14][N:15](C=CC)[C:16](=[O:17])[C:3]=12>CO.Cl>[OH:1][C:2]1[C:7](=[O:8])[N:6]([CH:9]([CH3:10])[CH3:11])[C:5](=[O:12])[N:4]2[CH2:13][CH2:14][NH:15][C:16](=[O:17])[C:3]=12参加物
4
実験手順
A solution of 9-hydroxy-7-isopropyl-2-(1-propenyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,6,8(7H)-trione (1.8 g, 6.4 mmol) in MeOH (15 mL) and 6 N aqueous HCl (10 mL) was heated to reflux for 1 h. The solvents were removed in vacuo and the residue was triturated in MeOH to give the title compound as a solid. HPLC RT=2.14 min (Method A); ES MS (M+H)=240; 1H NMR (400 MHz, DMSO-d6) δ 11.5 (v broad s, 1H), 9.19 (s, 1H), 5.04 (septet, J=7 Hz, 1H), 3.87 (t, J=7 Hz, 2H), 3.46 (m, 2H), 1.38 (d, J=7 Hz, 6H).