Hydrochloric Acid → HCID 178431468、化合物

HRID 1163066ノート

反応式

HRID 1163066 の反応式
[CH3:1][S:2]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[C:10]([CH3:25])=[C:11]2[N:16]([CH:17]=1)[N:15]=[CH:14][N:13]=[C:12]2[O:18]C1C=CC=CC=1)(=[O:4])=[O:3].Cl>C(O)C>[CH3:1][S:2]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[C:10]([CH3:25])=[C:11]2[N:16]([CH:17]=1)[N:15]=[CH:14][N:13]=[C:12]2[OH:18])(=[O:4])=[O:3]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 225088806-(3-Methanesulfonyl-propoxy)-5-methyl-4-phenoxypyrrolo[2,1-f][1,2,4]triazine

生成物 1

HCID 178431468HCID 178431468、化合物収率 95%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

A mixture of 6-(3-methanesulfonyl-propoxy)-5-methyl-4-phenoxypyrrolo[2,1-f][1,2,4]triazine (1.1 g, 3.04 mmol), HCl (1N, 20 mL) and ethanol (20 mL) was heated at 80° C. for 3 h. The volatiles were removed in vacuo. The white solid was triturated with diethyl ether/hexane (2:1) to afford 6-(3-methanesulfonyl-propoxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-ol (820 mg, 95%) as a white solid MS: (M+H)+=286.

後処理

  1. customThe volatiles were removed in vacuo
  2. customThe white solid was triturated with diethyl ether/hexane (2:1)

出典と根拠

ORDレコード
ord-f2ede436b17243819fbbc930cadbb708
出典データセット
uspto-grants-2010_10
特許番号
US07820814B2

反応ノート

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