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Levulinic Acid → 9-Methoxy-11b-methyl-1,2,5,6,11,11b-hexahydro-indolizino[8,7-b]indol-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Levulinic Acid | HCID 11579 | — |
| 反応物 | 2-(2-Aminoethyl)-5-methoxyindole | HCID 17654 | — |
| 溶媒 | 1-Ethoxyethanol | HCID 10129898 | — |
| 生成物 | 9-Methoxy-11b-methyl-1,2,5,6,11,11b-hexahydro-indolizino[8,7-b]indol-3-one | HCID 58970766 | 71.8% |
反応手順
A mixture of 6-methoxytryptamine (0.95 g, 5 mmol) and levulinic acid (0.7 g, 6 mmol) in ethoxyethanol is heated at ruflux temperature for 16 hours, cooled to room temperature and concentrated in vacuo to give 9-methoxy-11b-methyl-1,2,5,6,11,11b-hexahydro-indolizino[8,7-b]indol-3-one (0.97 g) identified by NMR, HPLC and MS [271.2 m/e (M+H)].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07820825B2 |
| 出典データセット | uspto-grants-2010_10 |
| ORD ID | ord-d1b0d087b438454ba17e4ca35b4036b7 |
| 出典メモ | uspto-grants-2010_10 |