Methanol → 5-(2-(4-Hydroxyphenyl)Ethenyl)Benzene-1,3-Diol

HRID 1163277

反応式

HRID 1163277 の反応式
C(O[C:5]1[CH:10]=[CH:9][C:8]([CH:11]=[CH:12][C:13]2[CH:18]=CC=[CH:15][CH:14]=2)=[C:7](OC(=O)C)[C:6]=1[O:23]C(=O)C)(=O)C.[C:27]([O-:30])(=O)[CH3:28].[NH4+].C[OH:33]>>[C:8]1([CH:11]=[CH:12][C:13]2[CH:18]=[CH:28][C:27]([OH:30])=[CH:15][CH:14]=2)[CH:7]=[C:6]([OH:23])[CH:5]=[C:10]([OH:33])[CH:9]=1

参加物

4

反応物 3

HCID 887MethanolHCID 517165Ammonium AcetateHCID 67170930HCID 67170930、化合物

生成物 1

HCID 50565-(2-(4-Hydroxyphenyl)Ethenyl)Benzene-1,3-Diol収率 97%

反応条件

温度
5 °C

実験手順

2.10 g (6.0 mmol) triacetoxystilbene were dissolved under reflux in 19.3 ml methanol and 39 ml ammonium acetate solution (25%) was added to the solution. The reaction mixture was stirred for three hours at the same temperature and afterwards the methanol was distilled off. By cooling to 5° C. the product crystallized and could be filtered off. 1.33 g (5.82 mmol, 97%) resveratrol were obtained as a pure compound. The mother liquor was purified by extraction with methyl-butyl-ether and neutralized with ammonia. After concentration under reduced pressure the solution was used again for the described reaction.

後処理

  1. distillationafterwards the methanol was distilled off
  2. customcrystallized
  3. filtrationcould be filtered off

出典と根拠

ORDレコード
ord-a39cd5814b8e4cfb83a268c64010e173
出典データセット
uspto-grants-2010_10
特許番号
US07820848B2

関連ノート

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