Water → 7-chloro-6-fluoro-1-(5-fluoro-pyridin-2-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic Acid

HRID 1163331ノート

反応式

HRID 1163331 の反応式
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[CH:10][C:11]([Cl:18])=[C:12]([F:17])[CH:13]=2)[N:8]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][N:20]=2)[CH:7]=1)=[O:5])C.O>C(O)(=O)C.Cl>[Cl:18][C:11]1[CH:10]=[C:9]2[C:14]([C:15](=[O:16])[C:6]([C:4]([OH:5])=[O:3])=[CH:7][N:8]2[C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][N:20]=2)=[CH:13][C:12]=1[F:17]

参加物

5

反応物 2

HCID 962WaterHCID 67274049HCID 67274049、化合物

生成物 1

HCID 672739937-chloro-6-fluoro-1-(5-fluoro-pyridin-2-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic Acid

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 313Hydrochloric Acid溶媒

反応条件

温度
90 °C

実験手順

A suspension of 0.5 g 7-chloro-6-fluoro-1-(5-fluoro-pyridin-2-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (1.37 mmol) in a mixture of 1.5 ml acetic acid and 1.5 ml 25% HCl was stirred at 90° C. over night. The reaction was monitored by HPLC. The suspension was poured into 50 ml water, the colorless crystals filtered and dried.

後処理

  1. filtrationthe colorless crystals filtered
  2. customdried

出典と根拠

ORDレコード
ord-6673dc493cf14f4fb829125619d9ed68
出典データセット
uspto-grants-2010_10
特許番号
US07820823B2

反応ノート

読み込み中…