Benzylamine → benzyl-[5-(1H-indazol-6-yloxy)-2-nitrophenyl]-amine

HRID 1163440

反応式

HRID 1163440 の反応式
Cl[C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[N+:18]([O-:20])=[O:19])[O:5][C:6]1[CH:14]=[C:13]2[C:9]([CH:10]=[N:11][NH:12]2)=[CH:8][CH:7]=1.[CH2:21]([NH2:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>CN(C=O)C>[CH2:21]([NH:28][C:2]1[CH:3]=[C:4]([O:5][C:6]2[CH:14]=[C:13]3[C:9]([CH:10]=[N:11][NH:12]3)=[CH:8][CH:7]=2)[CH:15]=[CH:16][C:17]=1[N+:18]([O-:20])=[O:19])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

参加物

4

反応物 2

HCID 7504BenzylamineHCID 684463516-(3-chloro-4-nitrophenoxy)-1H-indazole

生成物 1

HCID 68445941benzyl-[5-(1H-indazol-6-yloxy)-2-nitrophenyl]-amine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

A stirred solution of the nitro compound (2 mmol) in DMF (4 mL) was added with benzylamine (4 mmol) and contents were heated at 100° C. for 6 h. The reaction mixture was cooled to RT and the contents were poured onto ice cold water with vigorous stirring. The solid formed was collected by filtration, washed with water, and dried in vacuo. The residue obtained was purified on silica gel column chromatography using hexane/EtOAC as eluent to provide the product, benzyl-[5-(1H-indazol-6-yloxy)-2-nitrophenyl]-amine as a yellow solid.

後処理

  1. temperatureThe reaction mixture was cooled to RT
  2. additionthe contents were poured onto ice cold water with vigorous stirring
  3. customThe solid formed
  4. filtrationwas collected by filtration
  5. washwashed with water
  6. customdried in vacuo
  7. customThe residue obtained
  8. customwas purified on silica gel column chromatography

出典と根拠

ORDレコード
ord-d7cc111a1cf0407094d457dda9525ea0
出典データセット
uspto-grants-2010_10
特許番号
US07820821B2

関連ノート

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