Hydrochloric Acid → 2-Ethoxy-1-(4-hydroxy-3,5-di-tert-butylphenyl)-ethanone

HRID 1163471

反応式

HRID 1163471 の反応式
[OH-].[K+].Br[CH2:4][C:5]([C:7]1[CH:12]=[C:11]([C:13]([CH3:16])([CH3:15])[CH3:14])[C:10]([OH:17])=[C:9]([C:18]([CH3:21])([CH3:20])[CH3:19])[CH:8]=1)=[O:6].Cl.[CH2:23]([OH:25])[CH3:24]>>[CH2:23]([O:25][CH2:4][C:5]([C:7]1[CH:12]=[C:11]([C:13]([CH3:16])([CH3:15])[CH3:14])[C:10]([OH:17])=[C:9]([C:18]([CH3:21])([CH3:20])[CH3:19])[CH:8]=1)=[O:6])[CH3:24]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 6161612-Bromo-1-[3,5-di(tert-butyl)-4-hydroxyphenyl]ethan-1-one

生成物 1

HCID 577472312-Ethoxy-1-(4-hydroxy-3,5-di-tert-butylphenyl)-ethanone

実験手順

Under inert atmosphere 8.4 g (150 mmol) of potassium hydroxide is dissolved in 150 ml of ethanol. After adding 10.0 g (31 mmol) of 2-bromo-1-(4-hydroxy-3,5-di-tert-butylphenyl)-ethanone in portions at room temperature stirring is continued for 16 hours. Then the reaction mixture is acidified with 10% HCl and extracted with ethylacetate. The collected organic phases are washed with water and brine, dried and evaporated. Crystallization of the crude product from hexane gives 3.8 g of compound 113, m.p. 73-75° C.

後処理

  1. extractionextracted with ethylacetate
  2. washThe collected organic phases are washed with water and brine
  3. customdried
  4. customevaporated
  5. customCrystallization of the crude product from hexane

出典と根拠

ORDレコード
ord-fd8cb560517341caa04989e8aec8127b
出典データセット
uspto-grants-2010_10
特許番号
US07820865B2

関連ノート

読み込み中…