Toluene → HCID 131712929、化合物

HRID 1163911ノート

反応式

HRID 1163911 の反応式
[CH2:1]([NH:5][CH2:6][CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1)[CH2:2][CH2:3][CH3:4].[CH3:17][N:18]([C:23]([O:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[O:24])[CH:19]([CH3:22])C=O.[C:33]1(C)C=CC=CC=1>>[CH2:1]([N:5]1[CH:6]=[CH:7][C:8]2[C:9]([N:10]=[C:11]3[C:16]=2[CH:15]=[CH:14][CH:13]=[CH:12]3)=[CH:17]1)[CH2:2][CH2:3][CH3:4].[CH3:17][N:18]([CH2:19][CH2:22][C:33]1[N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[CH:6]=[CH:7][C:8]2[C:9]=1[N:10]=[C:11]1[C:16]=2[CH:15]=[CH:14][CH:13]=[CH:12]1)[C:23]([O:25][CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)=[O:24]

参加物

5

反応物 3

HCID 1140TolueneHCID 45582N-Butyl-1H-indole-3-ethanamineHCID 20513196HCID 20513196、化合物

生成物 2

HCID 131712929HCID 131712929、化合物HCID 131712930HCID 131712930、化合物

実験手順

To a solution of 3.4 g of N-n-butyl-tryptamine in 50 ml of toluene are added 4.6 g of N-methyl-N-benzyloxycarbonyl-2-aminopropionaldehyde, and the mixture is refluxed for 15 hours. After the reaction, the mixture is condensed under reduced pressure. Then, the residue obtained is purified by silica gel chromatography. 3.9 g of 1,2,3,4-tetrahydro-1-(2-N-methyl-N-benzyloxycarbonylamino)ethyl)-2-n-butyl-β-carboline (cis isomer) and 1.32 g of 1,2,3,4-tetrahydro-1-(2-(N-methyl-N-benzyloxycarbonylamino)ethyl-2-n-butyl-β-carboline (trans isomer) are obtained, respectively.

後処理

  1. temperaturethe mixture is refluxed for 15 hours
  2. customAfter the reaction
  3. customcondensed under reduced pressure
  4. customThen, the residue obtained
  5. customis purified by silica gel chromatography

出典と根拠

ORDレコード
ord-b3e85bcbf88e47baa43e6bc954019c97
出典データセット
uspto-grants-1983_01
特許番号
US04367230

反応ノート

読み込み中…