Hydrazine → HCID 54187452、化合物

HRID 11640ノート

反応式

HRID 11640 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:20][CH2:21][C:22]([N:24]2[CH2:29][C@H:28]([CH3:30])[N:27]([CH2:31][C:32]3[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=3)[CH2:26][C@H:25]2[CH3:39])=[O:23])=[C:6]([CH:19]=1)[CH2:7][N:8]1C(=O)C2C(=CC=CC=2)C1=O.NN>C(O)C>[NH2:8][CH2:7][C:6]1[CH:19]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[O:20][CH2:21][C:22]([N:24]1[CH2:29][C@H:28]([CH3:30])[N:27]([CH2:31][C:32]2[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=2)[CH2:26][C@H:25]1[CH3:39])=[O:23]

参加物

4

反応物 2

HCID 9321HydrazineHCID 696554042-(5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzyl)-isoindole-1,3-dione

生成物 1

HCID 54187452HCID 54187452、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To 2-(5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzyl)-isoindole-1,3-dione (0.87 g, 1.59 mmol) in ethanol (20 mL) was added 35% hydrazine (3 mL, 33.1 mmol). After 17 hours, the reaction was filtered and concentrated to a tan solid. This solid was triturated with methylene chloride and the title compound was obtained after filtration, drying over magnesium sulfate and concentrating in vacuo (0.62 g).

後処理

  1. filtrationthe reaction was filtered
  2. concentrationconcentrated to a tan solid
  3. customThis solid was triturated with methylene chloride

出典と根拠

ORDレコード
ord-3e772f25c01b4b32b32b3bd235b01aab
出典データセット
uspto-grants-2006_08
特許番号
US07098212B2

反応ノート

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