Water → HCID 20513473、化合物

HRID 1164082ノート

反応式

HRID 1164082 の反応式
[CH3:1][O:2][C:3]1[C:8]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:16])=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:17][C:18]#N.[OH-:20].[K+].[OH2:22]>C(O)C>[CH3:1][O:2][C:3]1[C:8]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:16])=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:17][C:18]([OH:22])=[O:20]

参加物

5

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 205134652-[2-Methoxy-3-(2-chlorophenylthio)phenyl]acetonitrile

生成物 1

HCID 20513473HCID 20513473、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-[2-methoxy-3-(2-chlorophenylthio)phenyl]acetonitrile (1.5 g) and potassium hydroxide (870 mg) in ethanol (40 ml) and water (20 ml) was refluxed under heating for 24 hours. The reaction mixture was evaporated under reduced pressure and the residue was dissolved in water. The aqueous solution was washed with diethyl ether, acidified with dil. hydrochloric acid and extracted with diethyl ether. The extract was washed with water, dried and then evaporated to give oily 2-[2-methoxy-3-(2-chlorophenylthio)phenyl]acetic acid (1.4 g).

後処理

  1. temperaturewas refluxed
  2. temperatureunder heating for 24 hours
  3. customThe reaction mixture was evaporated under reduced pressure
  4. dissolutionthe residue was dissolved in water
  5. washThe aqueous solution was washed with diethyl ether
  6. extractionextracted with diethyl ether
  7. washThe extract was washed with water
  8. customdried
  9. customevaporated

出典と根拠

ORDレコード
ord-a142a796e3684adfb481e70a1fcce0d7
出典データセット
uspto-grants-1983_01
特許番号
US04367238

反応ノート

読み込み中…