Sodium Chloride → 2-[2-Methoxy-3-(o-tolylthio)phenyl]acetonitrile

HRID 1164110ノート

反応式

HRID 1164110 の反応式
[C-:1]#[N:2].[Na+].[CH3:4][O:5][C:6]1[C:11]([CH2:12]Cl)=[CH:10][CH:9]=[CH:8][C:7]=1[S:14][C:15]1[C:16]([CH3:21])=[CH:17][CH:18]=[CH:19][CH:20]=1.[Cl-].[Na+]>CS(C)=O>[CH3:4][O:5][C:6]1[C:7]([S:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])=[CH:8][CH:9]=[CH:10][C:11]=1[CH2:12][C:1]#[N:2]

参加物

5

反応物 3

HCID 5234Sodium ChlorideHCID 8929Sodium CyanideHCID 20513475o-Tolyl 2-methoxy-3-chloromethylphenyl thioether

生成物 1

HCID 205134502-[2-Methoxy-3-(o-tolylthio)phenyl]acetonitrile収率 96%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

Powdered sodium cyanide (1.5 g) was added all at once to a solution of o-tolyl 2-methoxy-3-chloromethylphenyl thioether (8.3 g) in dimethyl sulfoxide (40 ml), and the mixture was stirred for 15 minutes, poured into saturated aqueous solution of sodium chloride and extracted with diethyl ether. The extract was washed with water, dried and then evaporated under reduced pressure to give oily 2-[2-methoxy-3-(o-tolylthio)phenyl]acetonitrile (7.7 g).

後処理

  1. extractionextracted with diethyl ether
  2. washThe extract was washed with water
  3. customdried
  4. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-ab22cb2c452e459a9e128506dbf3af59
出典データセット
uspto-grants-1983_01
特許番号
US04367238

反応ノート

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