Acetic Anhydride → 3-Methyl-7-(o-tolylthio)-2,3-dihydrobenzofuran-2-one
反応式
O[C:2]1[C:7]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:15])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:16]([CH3:20])[C:17]([OH:19])=[O:18].C(OC(=O)C)(=O)C>>[CH3:20][CH:16]1[C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[CH3:15])[C:2]=2[O:18][C:17]1=[O:19]参加物
3
実験手順
A mixture of 2-[2-hydroxy-3-(o-tolylthio)phenyl]propionic acid (2.0 g) and acetic anhydride (5 ml) was refluxed under heating and evaporated under reduced pressure. The residue was purified by column chromatography (silica gel 30 g, benzene) to give 3-methyl-7-(o-tolylthio)-2,3-dihydrobenzofuran-2-one (1.4 g).
後処理
- temperaturewas refluxed
- temperatureunder heating
- customevaporated under reduced pressure
- customThe residue was purified by column chromatography (silica gel 30 g, benzene)
出典と根拠
- ORDレコード
- ord-5fba9a8a67a54bcf9783b8989b6d6d1a
- 出典データセット
- uspto-grants-1983_01
- 特許番号
- US04367238
反応ノート
読み込み中…