1,4-Dibromobutane → 3-(4-Bromobutyl)-1,3-thiazolidine-2,4-dione
反応式
[Na].[S:2]1[CH2:6][C:5](=[O:7])[NH:4][C:3]1=[O:8].[Br:9][CH2:10][CH2:11][CH2:12][CH2:13]Br>CN(C)C=O>[Br:9][CH2:10][CH2:11][CH2:12][CH2:13][N:4]1[C:5](=[O:7])[CH2:6][S:2][C:3]1=[O:8]参加物
4
実験手順
The 2,4-thiazolidinedione sodium salt (13.91 g., 0.1 mole) is added to a solution of 1,4-dibromobutane (64.77 g., 0.3 mole) in 500 ml. of dry dimethylformamide. After stirring the mixture at room temperature for a 16 hr. period, the resulting clear solution is concentrated in vacuo and residual material dissolved in chloroform, filtered, and concentrated in vacuo to an amber oil. Distillation of the oil affords 20.62 g. (81% yield) of 3-(4-bromobutyl)-2,4-thiazolidinedione, b.p. 105°-115° C. at 0.02 mmHg.
後処理
- concentrationperiod, the resulting clear solution is concentrated in vacuo and residual material
- dissolutiondissolved in chloroform
- filtrationfiltered
- concentrationconcentrated in vacuo to an amber oil
- distillationDistillation of the oil
- customaffords 20.62 g
出典と根拠
- ORDレコード
- ord-36630187808c40098768ea1fe11b59f3
- 出典データセット
- uspto-grants-1983_01
- 特許番号
- US04367335
反応ノート
読み込み中…