Ammonia → Aniracetam

HRID 1164299

反応式

HRID 1164299 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1.[NH:12]1[CH2:16][CH2:15][CH2:14][C:13]1=[O:17].N>C(OCC)C>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([N:12]2[CH2:16][CH2:15][CH2:14][C:13]2=[O:17])=[O:8])=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 7477p-Anisoyl chlorideHCID 120252-Pyrrolidone

生成物 1

HCID 2196Aniracetam

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

20 g. of p-methoxybenzoyl chloride and 20 g. of 2-pyrrolidinone are boiled at reflux in 20 ml. of diethyl ether for 16 hours and then diethyl ether, ice and 2-N aqueous ammonia are added to the mixture. The insoluble constituents are filtered off and washed ion-free with diethyl ether and water. The filter cake is dried and there is obtained 1-(p-methoxybenzoyl)-2-pyrrolidinone having a melting point of 119.5°-120.5° C.

後処理

  1. temperatureat reflux in 20 ml
  2. filtrationThe insoluble constituents are filtered off
  3. washwashed ion-free with diethyl ether and water
  4. customThe filter cake is dried

出典と根拠

ORDレコード
ord-0bb0b4da28074479be7395265e460878
出典データセット
uspto-grants-1983_01
特許番号
US04369139

関連ノート

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