Water → 2-(4-Fluoro-2-methylphenyl)acetonitrile
反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:4]=1[CH3:10].[C-:11]#[N:12].[K+].O.[I-].[K+]>CC(=O)C>[F:9][C:6]1[CH:7]=[CH:8][C:3]([CH2:2][C:11]#[N:12])=[C:4]([CH3:10])[CH:5]=1参加物
6
実験手順
A mixture of 16 parts of 1-(chloromethyl)-4-fluoro-2-methylbenzene, 7.8 parts of a solution of potassium cyanide in a small amount of water, 0.1 parts of potassium iodide and 240 parts of 2-propanone is stirred and refluxed for 22 hours. The reaction mixture is cooled and filtered. The filtrate is evaported. The residue is taken up in water and the product is extracted with methylbenzene. The extract is dried, filtered and evaporated, yielding 13 parts (87.2%) of 4-fluoro-2-methylbenzeneacetonitrile as a residue.
後処理
- temperaturerefluxed for 22 hours
- temperatureThe reaction mixture is cooled
- filtrationfiltered
- extractionthe product is extracted with methylbenzene
- customThe extract is dried
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-a0e0556877194641b9d87def4b3ed5e7
- 出典データセット
- uspto-grants-1983_01
- 特許番号
- US04369184
反応ノート
読み込み中…