HCID 53792849、化合物 → HCID 54044274、化合物

HRID 1164369ノート

反応式

HRID 1164369 の反応式
C([N:3]([CH:13]([CH3:15])[CH3:14])[C:4]([C:6]1[NH:7][C:8]([Cl:12])=[C:9]([Cl:11])[N:10]=1)=[O:5])=O>S(=O)(=O)(O)O>[CH:13]([NH:3][C:4]([C:6]1[NH:7][C:8]([Cl:12])=[C:9]([Cl:11])[N:10]=1)=[O:5])([CH3:15])[CH3:14]

参加物

3

反応物 1

HCID 53792849HCID 53792849、化合物

生成物 1

HCID 54044274HCID 54044274、化合物収率 72%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

25 g (0.1 mol) of 4,5-dichloro-imidazole-2-carboxylic acid N-formyl-isopropylamide were stirred with 200 ml of concentrated sulphuric acid for about 15 minutes at 50°-70° C. After cooling, the mixture was poured onto ice and the product was filtered off, washed with water until neutral and dried. In this way, 16 g (72% of theory) of 4,5-dichloro-imidazole-2-carboxylic acid isopropylamide with a melting point of 150° C. were obtained.

後処理

  1. temperatureAfter cooling
  2. additionthe mixture was poured onto ice
  3. filtrationthe product was filtered off
  4. washwashed with water until neutral and
  5. customdried

出典と根拠

ORDレコード
ord-a90fb5a04fa941f188f83da3da3ef0c7
出典データセット
uspto-grants-1983_01
特許番号
US04369186

反応ノート

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