3-(Trifluoromethyl)aniline → HCID 20512399、化合物

反応式

Cl[CH:2]([CH3:15])[CH2:3][NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1.[F:16][C:17]([F:26])([F:25])[C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=1)[NH2:21]>>[F:12][C:11]([F:14])([F:13])[C:7]1[CH:6]=[C:5]([NH:4][CH2:3][CH:2]([NH:21][C:20]2[CH:22]=[CH:23][CH:24]=[C:18]([C:17]([F:16])([F:25])[F:26])[CH:19]=2)[CH3:15])[CH:10]=[CH:9][CH:8]=1

参加物

反応物 2

HCID 73753-(Trifluoromethyl)aniline

HCID 20512435HCID 20512435、化合物

生成物 1

HCID 20512399HCID 20512399、化合物収率 76.6%

実験手順

N-(β-Chloropropyl)-3-trifluoromethyl-aniline is reacted with 3-trifluoromethylaniline as described in Example 16, point (c) to obtain 1,2-bis(3'-trifluoromethylphenyl-amino)-propane with a yield of 76.6%. The dihydrochloride of this base melts at 116°-120° C.

出典と根拠

ORDレコード: ord-a595dd98d9aa4915a1f6b9ef88746c89
出典データセット: uspto-grants-1983_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04369325

反応ノート

読み込み中…