Hydrochloric Acid → N-[2-(Piperidin-4-yl)ethyl]methanesulfonamide--hydrogen chloride (1/1)

HRID 1164506ノート

反応式

HRID 1164506 の反応式
[CH3:1][S:2]([NH:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)(=[O:4])=[O:3].[ClH:14].[H][H]>C(O)C.[Pt]=O>[ClH:14].[CH3:1][S:2]([NH:5][CH2:6][CH2:7][CH:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)(=[O:3])=[O:4]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 2797875HCID 2797875、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 20511180N-[2-(Piperidin-4-yl)ethyl]methanesulfonamide--hydrogen chloride (1/1)

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒2 回

実験手順

4-(2-methanesulphonamidoethyl)pyridine (8.4 g.) in ethanol (85 ml.) was acidified to pH 2 with 2 N HCl and hydrogenated at room temperature and a pressure of 50 p.s.i. over a platinum oxide catalyst until hydrogen uptake ceased. The catalyst was then removed by filtration and the filtrate was taken to dryness in vacuo to give a white solid which was dissolved in the minimum volume of hot ethanol, filtered quickly, and left at room temperature overnight. The resultant white crystals were collected by filtration and dried to yield 4-(2-methanesulphonamidoethyl)piperidine hydrochloride (8.3 g.), m.p. 165°-167° C.

後処理

  1. customThe catalyst was then removed by filtration
  2. customto give a white solid which
  3. filtrationfiltered quickly
  4. filtrationThe resultant white crystals were collected by filtration
  5. customdried

出典と根拠

ORDレコード
ord-fd2fe8615190497599dec3d452df03cd
出典データセット
uspto-grants-1983_01
特許番号
US04370328

反応ノート

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