Ammonia → 2-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-4H,6H-1,3,4-thiadiazin-5-one

HRID 1164804

反応式

HRID 1164804 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.O1[CH:20]=[CH:19][C:18](=[O:21])[CH:17]=[CH:16]1.Cl.N>O>[O:21]=[C:18]1[CH:19]=[CH:20][N:1]([C:2]2[CH:3]=[CH:4][C:5]([C:8]3[S:9][CH2:10][C:11](=[O:14])[NH:12][N:13]=3)=[CH:6][CH:7]=2)[CH:16]=[CH:17]1

参加物

6

反応物 4

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 79684H-pyran-4-oneHCID 150456452-(4-aminophenyl)-4H,6H-1,3,4-thiadiazin-5-one

生成物 1

HCID 197942152-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-4H,6H-1,3,4-thiadiazin-5-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A stirred mixture of 2-(4-aminophenyl)-4H,6H-1,3,4-thiadiazin-5-one (1.0 g), 4H-pyran-4-one (0.51 g), water (20 ml) and concentrated hydrochloric acid (0.42 ml), was heated under reflux for 3 hours. The warm solution was neutralised with concentrated aqueous ammonia and cooled to give a solid, 1.33 g. Recrystallisation from methanol gave the title compound, 0.89 g, m.p. 289°-291° C.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours
  3. temperaturecooled
  4. customto give a solid, 1.33 g
  5. customRecrystallisation from methanol

出典と根拠

ORDレコード
ord-5aa274500dde4fa3a1562ec6f6427140
出典データセット
uspto-grants-1990_03
特許番号
US04906628

関連ノート

読み込み中…