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N-Methylethylenediamine → 3,5-diamino-6-chloro-N-(2-methylaminoethyl)pyrazine-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Methylethylenediamine | HCID 8014 | — |
| 反応物 | (3,5-diamino-6-chloropyrazin-2-yl)(1H-imidazol-1-yl)methanone | HCID 13020010 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3,5-diamino-6-chloro-N-(2-methylaminoethyl)pyrazine-2-carboxamide | HCID 19861822 | 85% |
反応手順
A mixture of 24.0 g (100.0 mmol) of 1-(3,5-diamino-6-chloropyrazinoyl)imidazole (see U.S. Pat. No. 4,029,816 as an example of how to obtain this material) and 13.6l g (183.5 mmol) of N-methylethylenediamine in 100 ml of tetrahydrofuran was stirred at ambient temperature for 18 hours. The reaction mixture was filtered and evaporated. The residue was crystallized from 2-propanol to give 20.8 g (85.0 mmol, 85%) of 3,5-diamino-6-chloro-N-(2-methylaminoethyl)pyrazine-2-carboxamide; mp 142.5°-143° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04906633 |
| 出典データセット | uspto-grants-1990_03 |
| ORD ID | ord-b912c3cef26242b6b9b679f1c6c03318 |
| 出典メモ | uspto-grants-1990_03 |