Ethyl 4-(2-hydroxyethyl)picolinate → Ethyl 4-(2-hydroxyethyl)piperidine-2-carboxylate
反応式
[OH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=1>C(O)(=O)C.[Pt]=O>[OH:1][CH2:2][CH2:3][CH:4]1[CH2:9][CH2:8][NH:7][CH:6]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:5]1参加物
4
実験手順
A mixture of 8.37 g of ethyl 4-(2-hydroxyethyl)-pyridine-2-carboxylate in 130 ml acetic acid and 4 g platinum oxide is hydrogenated at 50 lbs/in2. Filtration, concentration in vacuo, neutralization with potassium carbonate and extraction with methylene chloride yields an oil that is purified by flash chromatography using methylene chloride/methanol saturated with ammonia (20:1) to yield ethyl 4-(2-hydroxyethyl)-piperidine-2-carboxylate.
後処理
- filtrationFiltration, concentration in vacuo, neutralization
- extractionwith potassium carbonate and extraction with methylene chloride
- customyields an oil that
- customis purified by flash chromatography
出典と根拠
- ORDレコード
- ord-b3509b3edc2448d9a9e9b29a1af9ef18
- 出典データセット
- uspto-grants-1990_03
- 特許番号
- US04906621
反応ノート
読み込み中…