Boron tribromide → 2-(3-Amino-3-methylbutyl)phenol
反応式
[NH2:1][C:2]([CH3:14])([CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12]C)[CH3:3].B(Br)(Br)Br>C(Cl)Cl>[NH2:1][C:2]([CH3:14])([CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[OH:12])[CH3:3]参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a cold (0° C.) solution of 986 mg (5.1 mmol) of 2-amino-2-methyl-4-(2-methoxyphenyl)butane in 20 ml of dry methylene chloride, a solution of 2.5 ml of a 1M BBr3 solution in 10 ml of methylene chloride is slowly added. The reaction mixture is stirred at 0° C. for two hours and then at room temperature for 3 hours. The reaction is quenched with methanol and concentrated. Pure product may be obtained by chromatography on silica gel.
後処理
- waitat room temperature for 3 hours
- customThe reaction is quenched with methanol
- concentrationconcentrated
- customPure product may be obtained by chromatography on silica gel
出典と根拠
- ORDレコード
- ord-c956abd3e0b54d23b5c05a3624702051
- 出典データセット
- uspto-grants-1990_03
- 特許番号
- US04906645
反応ノート
読み込み中…