(R)-2-(tetrazolo[1,5-a]pyrid 6-yl)oxirane → HCID 18637940、化合物
反応式
[N:1]1[N:2]=[N:3][N:4]2[CH:9]=[C:8]([C@@H:10]3[CH2:12][O:11]3)[CH:7]=[CH:6][C:5]=12.[NH2:13][C:14]([CH3:25])([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[OH:24])[CH3:15]>C(O)C>[CH3:25][C:14]([NH:13][CH2:12][C@@H:10]([C:8]1[CH:7]=[CH:6][C:5]2[N:4]([N:3]=[N:2][N:1]=2)[CH:9]=1)[OH:11])([CH3:15])[CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[OH:24]参加物
4
実験手順
A solution of 156 mg (1.46 mmol) of (R)-2-(tetrazolo[1,5-a]pyrid-6-yl)oxirane and 170 ml of 2-amino-2-methyl-4-(2-hydroxyphenyl)butane in 15 ml of absolute ethanol is heated at reflux for 6 hours. The reaction mixture is concentrated and the residue chromatographed on silica gel to give the desired product.
後処理
- temperatureat reflux for 6 hours