Epichlorohydrin → HCID 19863794、化合物

HRID 1164932ノート

反応式

HRID 1164932 の反応式
[OH:1][CH:2]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH2:15]([CH:17]1[O:19][CH2:18]1)Cl.[OH-].[K+]>C(O)C.O>[OH:1][CH:2]([C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=1)[O:14][CH2:15][CH:17]1[CH2:18][O:19]1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

参加物

6

反応物 3

HCID 7835EpichlorohydrinHCID 14797Potassium HydroxideHCID 117900843-(1-Hydroxyhexyl)phenol

生成物 1

HCID 19863794HCID 19863794、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒2 回HCID 962Water溶媒

実験手順

19.4 g. (0.1 mole) 3-(1-hydroxyhexyl)-phenol and 28.6 g. epichlorohydrin are dissolved in 25 ml. ethanol and heated to the boil. A solution of 6.6 g. potassium hydroxide in 3 ml. water and 25 ml. ethanol is then added dropwise thereto in the course of 15 minutes. The reaction mixture is boiled under reflux for 2 hours, the solvent is then distilled off and the residue is taken up in water. Extraction is carried out with ethyl acetate, the ethyl acetate phase is washed twice with aqueous sodium hydroxide solution and water, dried and evaporated to give 22.4 g. (89% of theory) of the title compound in the form of an oil.

後処理

  1. customin the course of 15 minutes
  2. temperatureunder reflux for 2 hours
  3. distillationthe solvent is then distilled off
  4. extractionExtraction
  5. washthe ethyl acetate phase is washed twice with aqueous sodium hydroxide solution and water
  6. customdried
  7. customevaporated
  8. customto give 22.4 g

出典と根拠

ORDレコード
ord-c8c56db0a61c438c80c6863e81f2eb53
出典データセット
uspto-grants-1990_03
特許番号
US04906666

反応ノート

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