Methanol → Methyl 3-(2-hydroxyphenyl)prop-2-enoate

HRID 1164998

反応式

HRID 1164998 の反応式
[OH:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([OH:8])=[O:7].[CH3:13]O>S(=O)(=O)(O)O>[OH:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([O:8][CH3:13])=[O:7]

参加物

4

反応物 2

HCID 887MethanolHCID 119683-(2-Hydroxyphenyl)-2-propenoic acid

生成物 1

HCID 89400Methyl 3-(2-hydroxyphenyl)prop-2-enoate収率 92%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

実験手順

A solution of 200 g (1.218 mole) of 2-hydroxycinnamic acid in 2L of anhydrous methanol was treated with 10 drops of concentrated sulfuric acid. This solution was refluxed for 72 hr., using a Soxhlet extractor charged with 200 g of 3A molecular sieves. The methanolic solution was then concentrated under reduced pressure and cooled to afford 200 g (92%) of white crystals, which were used directly in the next step without additional purification.

後処理

  1. temperatureThis solution was refluxed for 72 hr
  2. concentrationThe methanolic solution was then concentrated under reduced pressure
  3. temperaturecooled

出典と根拠

ORDレコード
ord-be57951fd8e942fcb9f559f8ba454413
出典データセット
uspto-grants-1990_03
特許番号
US04906661

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