2-Chlorobenzylamine → N-((2-chlorophenyl)methyl)thiophene-2-ethylamine hydrochloride
反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7]O.C1(C)C=CC(S(OCCC2SC=CC=2)(=O)=O)=CC=1.[Cl:27][C:28]1[CH:35]=[CH:34][CH:33]=[CH:32][C:29]=1[CH2:30][NH2:31]>>[ClH:27].[Cl:27][C:28]1[CH:35]=[CH:34][CH:33]=[CH:32][C:29]=1[CH2:30][NH:31][CH2:7][CH2:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
Another synthetic route involved preparation of a 2-(2-thienyl)ethanol, its conversion to 2-(2-thienyl)ethyl paratoluene sulfonate and benzylation with o-chlorobenzylamine to give N-(2-chloro-benzyl)-2-(2-thienyl)ethylamine hydrochloride, which is cyclized to give ticlopidine free base, as described by Braye in U.S. Pat. No. 4,127,580.
出典と根拠
- ORDレコード
- ord-9821706cd9774fa6b5013d08f0448b02
- 出典データセット
- uspto-grants-1990_03
- 特許番号
- US04906756
反応ノート
読み込み中…