Methyl 2-cyanonicotinate → HCID 19862615、化合物

HRID 1165164ノート

反応式

HRID 1165164 の反応式
C[O-].[Na+].[C:4]([C:6]1[N:15]=[CH:14][CH:13]=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9])#[N:5].[Cl:16][C:17]1[CH:18]=[C:19]([C:23]2[S:24][CH:25]=[C:26](CO)[N:27]=2)[CH:20]=[CH:21][CH:22]=1>C1(C)C=CC=CC=1>[C:4]([C:6]1[N:15]=[CH:14][CH:13]=[CH:12][C:7]=1[C:8]([O:10][CH2:11][C:26]1[N:27]=[C:23]([C:19]2[CH:20]=[CH:21][CH:22]=[C:17]([Cl:16])[CH:18]=2)[S:24][CH:25]=1)=[O:9])#[N:5]

参加物

5

反応物 3

HCID 339115Methyl 2-cyanonicotinateHCID 10942334Sodium MethoxideHCID 14330272(2-(3-Chlorophenyl)thiazol-4-yl)methanol

生成物 1

HCID 19862615HCID 19862615、化合物収率 25.3%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Sodium methylate (0.11 g; 0.002 mole) is added to a solution of methyl 2-cyanonicotinate (3.24 g; 0.02 mole) and 2-(3-chlorophenyl)-4-(hydroxymethyl)thiazole (4.96 g; 0.022 mole) in toluene (100 cc). The methanol/toluene azeotrope is distilled off and the toluene is then evaporated off. The residue is treated with water. The precipitate formed is filtered off, washed with water and then dried. Compound 2 (1.8 g; 25% m.p. 130° C.) is obtained.

後処理

  1. distillationThe methanol/toluene azeotrope is distilled off
  2. customthe toluene is then evaporated off
  3. additionThe residue is treated with water
  4. customThe precipitate formed
  5. filtrationis filtered off
  6. washwashed with water
  7. customdried

出典と根拠

ORDレコード
ord-77eb3f77bea946e49e5d3dd9a4f13441
出典データセット
uspto-grants-1990_03
特許番号
US04908375

反応ノート

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