Hydrochloric Acid → 8-Cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)-3-quinolinecarboxylic acid

HRID 1165366ノート

反応式

HRID 1165366 の反応式
Cl[C:2]1[C:11]([C:12]#[N:13])=[C:10]2[C:5]([C:6](=[O:20])[C:7]([C:17]([OH:19])=[O:18])=[CH:8][N:9]2[CH:14]2[CH2:16][CH2:15]2)=[CH:4][C:3]=1[F:21].[NH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1.Cl>O1CCOCC1>[C:12]([C:11]1[C:2]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[C:3]([F:21])[CH:4]=[C:5]2[C:10]=1[N:9]([CH:14]1[CH2:16][CH2:15]1)[CH:8]=[C:7]([C:17]([OH:19])=[O:18])[C:6]2=[O:20])#[N:13]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 4837PiperazineHCID 153471917-Chloro-8-cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

生成物 1

HCID 197766128-Cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)-3-quinolinecarboxylic acid

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

0.5 g of the product from Example 1 and 0.42 g of piperazine are boiled in 8 ml of dioxane for 3 hours. The mixture is then concentrated in vacuo and 8 ml of water are added to the residue. The solution formed is rendered neutral with HCl and the solid which has precipitated out isolated, washed and dried.

後処理

  1. concentrationThe mixture is then concentrated in vacuo and 8 ml of water
  2. additionare added to the residue
  3. customThe solution formed
  4. customthe solid which has precipitated out
  5. customisolated
  6. washwashed
  7. customdried

出典と根拠

ORDレコード
ord-9039e2d03ffd425f80d6c46641153fa2
出典データセット
uspto-grants-1990_03
特許番号
US04908366

反応ノート

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