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Glycerol → 4-(Acetyloxy)-2-butanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Glycerol | HCID 753 | — |
| 反応物 | Ethyl Acetoacetate | HCID 8868 | — |
| 反応物 | 4-Hydroxy-2-Butanone | HCID 111509 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(Acetyloxy)-2-butanone | HCID 139100 | 61% |
反応手順
The method described in Example 5 is followed starting with glycerol and 4-hydroxy-2-butanone, suitably protected at the hydroxy group with an acetyl radical. 4-acetoxy-2-butanone is prepared starting from ethyl acetoacetate, protected at the carbonyl group as diethylacetal, by reduction with lithium-aluminium hydride, followed by restoring the keto group by means of silica in the presence of water (A: Banerje 8 G. P. Kalena, Synth. Commun (1982) 12, 225). 1,3-dioxolane-2-methyl-2'-(2-hydroxyethyl-4-acetylthiomethylene distills at 164°-170° C. (10 mm Hg). Yield 61%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04910220 |
| 出典データセット | uspto-grants-1990_03 |
| ORD ID | ord-2e7d0c3e6c13486b814b78a283fe37cb |
| 出典メモ | uspto-grants-1990_03 |