Dimethylformamide → 6-Chloro-1,3-diethyl-5-formyluracil

HRID 1165776ノート

反応式

HRID 1165776 の反応式
[CH2:1]([N:3]1[C:10](=[O:11])[CH2:9][C:7](=O)[N:6]([CH2:12][CH3:13])[C:4]1=[O:5])[CH3:2].CN(C)[CH:16]=[O:17].P(Cl)(Cl)([Cl:21])=O>>[Cl:21][C:7]1[N:6]([CH2:12][CH3:13])[C:4](=[O:5])[N:3]([CH2:1][CH3:2])[C:10](=[O:11])[C:9]=1[CH:16]=[O:17]

参加物

4

反応物 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 1228891,3-Diethylbarbituric acid

生成物 1

HCID 126779796-Chloro-1,3-diethyl-5-formyluracil

実験手順

To a solution of 1,3-diethylbarbituric acid (61 g) in phosphorus oxychloride (224 ml) was added dimethylformamide (35 ml) with stirring at room temperature and then the reaction solution was refluxed for 3.5 hr. The solution was concentrated to dryness to give an oil. The oil was poured into ice-water to give crystals, 6-chloro-1,3-diethyl-5-formyluracil (64 g), m.p. 88°-89° C.

後処理

  1. temperaturethe reaction solution was refluxed for 3.5 hr
  2. concentrationThe solution was concentrated to dryness
  3. customto give an oil

出典と根拠

ORDレコード
ord-e203105119c94901bb1ddb08b97df94c
出典データセット
uspto-grants-1990_03
特許番号
US04912104

反応ノート

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