Hydrochloric Acid → trans-1-Benzoyl-4-phenyl-l-proline

HRID 1165965

反応式

HRID 1165965 の反応式
[Cl-].[Cl-].[Cl-].[Al+3].[C:5]([N:13]1[CH2:20][C@@H:19](F)[CH2:18][C@H:14]1[C:15]([OH:17])=[O:16])(=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.Cl>C1C=CC=CC=1>[C:5]([N:13]1[CH2:20][C@H:19]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:18][C@H:14]1[C:15]([OH:17])=[O:16])(=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 6451240Aluminum(III) ChlorideHCID 14584914(cis)-1-Benzoyl-4-fluoro-L-proline

生成物 1

HCID 46864073trans-1-Benzoyl-4-phenyl-l-proline

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A suspension of aluminum trichloride (191 mg, 1.43 mmole) in benzene (5 ml) was stirred under argon and treated with Part B (cis)-N-benzoyl-4-fluoro-L-proline (100 mg, 0.42 mmole). The reaction was stirred at room temperature for 20 hours, cooled to 0° C. and hydrolyzed with 1N HCl. The layers were separated and the aqueous layer was extracted with ethyl acetate. The organic extracts were combined, washed with brine, dried and concentrated. The residue consisted of

後処理

  1. stirringThe reaction was stirred at room temperature for 20 hours
  2. customThe layers were separated
  3. extractionthe aqueous layer was extracted with ethyl acetate
  4. washwashed with brine
  5. customdried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-5d1c8a6155244098807a146718398f92
出典データセット
uspto-grants-1990_03
特許番号
US04912231

関連ノート

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