Aluminum(III) Chloride → trans-1-Benzoyl-4-phenyl-l-proline

HRID 1165972

反応式

HRID 1165972 の反応式
[Cl-].[Cl-].[Cl-].[Al+3].[C:5]([N:13]1[CH2:20][C@@H:19](OS(C2C=CC(C)=CC=2)(=O)=O)[CH2:18][C@H:14]1[C:15]([OH:17])=[O:16])(=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C1C=CC=CC=1>[C:5]([N:13]1[CH2:20][C@H:19]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:18][C@H:14]1[C:15]([OH:17])=[O:16])(=[O:12])[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

参加物

4

反応物 2

HCID 6451240Aluminum(III) ChlorideHCID 53847232(cis)-1-benzoyl-4-tosyloxy-L-proline

生成物 1

HCID 46864073trans-1-Benzoyl-4-phenyl-l-proline

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

反応条件

温度
0 °C

実験手順

To a dry flask was added aluminum trichloride (58 mg, 0.435 mmole) and benzene (3 ml). While stirring under argon, (cis)-1-benzoyl-4-tosyloxy-L-proline (50 mg, 0.128 mmole) was added. After further stirring overnight, the reaction was cooled to 0° C. and quenched with 1N HCl. The resulting mixture was extracted with ethyl acetate and the organic extracts were washed with brine, dried, and concentrated in vacuo. The residue consisted of:

後処理

  1. stirringAfter further stirring overnight
  2. customquenched with 1N HCl
  3. extractionThe resulting mixture was extracted with ethyl acetate
  4. washthe organic extracts were washed with brine
  5. customdried
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-a18c09f3d7dd49a59ba6e1fe620710c6
出典データセット
uspto-grants-1990_03
特許番号
US04912231

関連ノート

読み込み中…