化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → 6-Chloro-1,2,3,4-tetrahydrocarbazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | 2-(5-Chloro-2-nitrophenyl)cyclo-hexanone | HCID 13348342 | — |
| 触媒 | Iron | HCID 23925 | — |
| 触媒 | Eisenazetat | HCID 45051903 | — |
| 溶媒 | Water ethanol | HCID 19096565 | — |
| 生成物 | 6-Chloro-1,2,3,4-tetrahydrocarbazole | HCID 326615 | 20% |
反応手順
The reduction can also be carried out using Fe/acetic acid. A mixture of 0.784 g of iron, 1.62 mL of glacial acetic acid, 0.544 g of sodium acetate, and 1 g of 2-(5-chloro-2-nitrophenyl)cyclo-hexanone was refluxed in 80 mL of 4:1 (v/v) ethanol/water for 2 hr. The mixture was cooled, ethanol was evaporated, and the residue was extracted into methylene chloride. Work-up followed by column chromatography on silica yielded 0.160 g (20%) of the named product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04912220 |
| 出典データセット | uspto-grants-1990_03 |
| ORD ID | ord-28f39c64974e44e39a86a9a573fd0459 |
| 出典メモ | uspto-grants-1990_03 |