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Triacetoxyperiodinane → 3-(3-Quinolinyl)-2-propynal
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triacetoxyperiodinane | HCID 159087 | — |
| 反応物 | 3-Quinolin-3-ylprop-2-yn-1-ol | HCID 650142 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-(3-Quinolinyl)-2-propynal | HCID 22630772 | 72.6% |
反応手順
A mixture of 3-(3-quinolinyl)-2-propyn-1-ol (prepared as described in J. Med Chem. 1996, 39, 3179) (360 mg, 1.96 mmol) and the Dess-Martin reagent (1.00 g, 2.36 mmol) in dichloromethane (10 mL) was stirred at RT for 1.5 h. The solution was washed with sat. aq. NaHCO3 and brine, dried (MgSO4), and concentrated. Purification by chromatography (SiO2, 1:4 hexane/ethyl acetate) yielded 258 mg (72%) of the title compound. MS 182 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06613747B2 |
| 出典データセット | uspto-grants-2003_09 |
| ORD ID | ord-64cd140bd5b64aae8b288f6161cea79c |
| 出典メモ | uspto-grants-2003_09 |