Phosphorus oxychloride → 2-(4-Chlorophenyl)-4-chloro-6,7,8-trimethoxyquinazoline

HRID 1166147ノート

反応式

HRID 1166147 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16](O)[C:15]3[C:10](=[C:11]([O:23][CH3:24])[C:12]([O:21][CH3:22])=[C:13]([O:19][CH3:20])[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:27])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16]([Cl:27])[C:15]3[C:10](=[C:11]([O:23][CH3:24])[C:12]([O:21][CH3:22])=[C:13]([O:19][CH3:20])[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 178486767HCID 178486767、化合物

生成物 1

HCID 117834712-(4-Chlorophenyl)-4-chloro-6,7,8-trimethoxyquinazoline

実験手順

18.2 g of 2-(4-chlorophenyl)-hydroxy-6,7,8-trimethoxyquinazoline were heated at 100° C. for 3 h in 120 ml of phosphorus oxychloride. The excess phosphorus oxychloride was distilled off and the oily residue was stirred with ice water. The solid was filtered off with suction and dried under reduced pressure. Yield: 15.0 g. M.p.: 159° C.

後処理

  1. distillationThe excess phosphorus oxychloride was distilled off
  2. filtrationThe solid was filtered off with suction
  3. customdried under reduced pressure

出典と根拠

ORDレコード
ord-f7ab9f2dd19e434aa7fb150c69033950
出典データセット
uspto-grants-2003_09
特許番号
US06613772B1

反応ノート

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