1-Benzylpiperazine → 2-(4-Chlorophenyl)-4-(4-benzylpiperazino)-6,7,8-trimethoxyquinazoline

HRID 1166151ノート

反応式

HRID 1166151 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16](Cl)[C:15]3[C:10](=[C:11]([O:23][CH3:24])[C:12]([O:21][CH3:22])=[C:13]([O:19][CH3:20])[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1.[CH2:25]([N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16]([N:35]3[CH2:36][CH2:37][N:32]([CH2:25][C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)[CH2:33][CH2:34]3)[C:15]3[C:10](=[C:11]([O:23][CH3:24])[C:12]([O:21][CH3:22])=[C:13]([O:19][CH3:20])[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 759941-BenzylpiperazineHCID 117834712-(4-Chlorophenyl)-4-chloro-6,7,8-trimethoxyquinazoline

生成物 1

HCID 111239992-(4-Chlorophenyl)-4-(4-benzylpiperazino)-6,7,8-trimethoxyquinazoline

反応条件

温度
150 °C

実験手順

A mixture of 2.0 g of 2-(4-chlorophenyl)-4-chloro-6,7,8-trimethoxyquinazoline and 5.0 g of N-benzylpiperazine was heated at 150° C. for 1 h. After cooling, 20 ml of ice water were added and the mixture was extracted with ethyl acetate. The organic phase was dried over sodium sulfate and concentrated. The oily crude product thus obtained was recrystallized from isopropanol. Yield: 1 g. M.p.: 150° C.

後処理

  1. temperatureAfter cooling
  2. extractionthe mixture was extracted with ethyl acetate
  3. dry with materialThe organic phase was dried over sodium sulfate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-6747592a7e76453cb68696400a8b36fa
出典データセット
uspto-grants-2003_09
特許番号
US06613772B1

反応ノート

読み込み中…