化工社化工社 化学情報印刷レポート · 研究参考用
Methyl iodide → 1-Chloro-4-methoxy-2-methyl-5-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Chloro-5-methyl-2-nitrophenol | HCID 23532 | — |
| 生成物 | 1-Chloro-4-methoxy-2-methyl-5-nitrobenzene | HCID 15864566 | 97.3% |
反応手順
4-Chloro-5-methyl-2-nitroanisole was prepared by the same procedure as described for Step 2 of Preparation 2a except using 4-chloro-5-methyl-2-nitrophenol (50 g), methyl iodide (75.8 g), and potassium carbonate (44 g). Workup gave crude 4-chloro-5-methyl-2-nitroanisole (52.3 g, 97%) which was used in the next step without purification. 1H NMR (300 MHz, CDCl3) δ7.85 (s, 1 H), 6.95 (s, 1 H), 3.94 (s, 3 H), 2.45 (s, 3 H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06613786B2 |
| 出典データセット | uspto-grants-2003_09 |
| ORD ID | ord-6cdaa4c65f6b40d1b63eb5d209868180 |
| 出典メモ | uspto-grants-2003_09 |