関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Isopropyl isocyanate | HCID 61277 | — |
| 反応物 | Undec-4-ene | HCID 136496 | — |
| 反応物 | 5-Chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzenesulfonamide | HCID 69295758 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | HCID 69655639 | HCID 69655639 | 72.1% |
反応手順
To a solution of 5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzenesulfonamide (0.07 g, 0.150 mmol) in tetrahydrofuran (1.5 mL) was added isopropyl isocyanate (0.022 mL, 0.23 mmol) and 1,8-diazabycyclo[5.4.0 ]undec-7-ene (0.034 mL, 0.23 mmol). The reaction was stirred at 60° C. overnight. The reaction was concentrated and purified by chromatography on silica gel to give the title compound (0.06 g, LRMS: 555.2)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07098212B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-d8759245b3184530ae3ccbb2fb865cd4 |
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| 出典メモ | uspto-grants-2006_08 |
|---|
