3-[4-(1-Methylethyl)phenyl]-3-buten-2-ol → 3-[4-(1-Methylethyl)phenyl]-3-buten-2-one
反応式
[CH3:1][CH:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10](=[CH2:14])[CH:11]([OH:13])[CH3:12])=[CH:6][CH:5]=1)[CH3:3]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:3][CH:2]([C:4]1[CH:5]=[CH:6][C:7]([C:10](=[CH2:14])[C:11](=[O:13])[CH3:12])=[CH:8][CH:9]=1)[CH3:1]参加物
4
実験手順
2.75 g of alcohol 45 is dissolved in 300 ml of methylene chloride, and 25.1 g of manganese dioxide is added under nitrogen. It is stirred overnight at room temperature, filtered on Celite, and the residue is chromatographed on silica gel with ethyl acetate/hexane, whereby 937 mg of title compound 46 in addition to 635 mg of the starting material is obtained as colorless oils.
後処理
- filtrationfiltered on Celite
- customthe residue is chromatographed on silica gel with ethyl acetate/hexane, whereby 937 mg of title compound 46 in addition to 635 mg of the starting material
- customis obtained as colorless oils
出典と根拠
- ORDレコード
- ord-46670eeb990f4cc4b4c766c888a6dd76
- 出典データセット
- uspto-grants-2003_09
- 特許番号
- US06613920B1
反応ノート
読み込み中…