HCID 12088903、化合物 → 4-Ethyl-6-methoxy-1,1,7-trimethyl-1,2-dihydronaphthalene

HRID 1166641ノート

反応式

HRID 1166641 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([CH3:15])([CH3:14])[CH2:8][CH2:9][C:10]2=O)=[CH:5][C:4]=1[CH3:16].[CH3:17][CH2:18][Mg+].[Br-]>>[CH2:17]([C:10]1[C:11]2[C:6](=[CH:5][C:4]([CH3:16])=[C:3]([O:2][CH3:1])[CH:12]=2)[C:7]([CH3:15])([CH3:14])[CH2:8][CH:9]=1)[CH3:18]

参加物

3

反応物 2

HCID 12088903HCID 12088903、化合物2 回HCID 178461630HCID 178461630、化合物

生成物 1

HCID 222183394-Ethyl-6-methoxy-1,1,7-trimethyl-1,2-dihydronaphthalene収率 63%

実験手順

Following General Procedure A, 7-methoxy-4,4,6-trimethyl-3,4-dihydro-2H-naphthalen-1-one (Compound 6, 0.5 g, 2.3 mmol) was reacted with a solution of 3M EtMgBr (2.3 mL, 6.9 mmol), and the crude product was purified by flash chromatography (hexane:ethyl acetate=4:1) to give 0.33 g (63%) of the title compound as a clear oil. PNMR (300 MHz, CDCl3) δ 1.32 (t, 3H, J=6.3 Hz), 1.38 (s, 6H), 2.32 (d, 2H, J=4.5 Hz), 2.42 (s, 3H), 2.65 (m, 2H), 3.98 (s, 3H), 5.88 (t, 1H, J=2.5 Hz), 6.96 (s, 1H), 7.28 (s, 1H).

後処理

  1. customthe crude product was purified by flash chromatography (hexane:ethyl acetate=4:1)

出典と根拠

ORDレコード
ord-070ccc8cfde848759af95bf1f0ce8a7b
出典データセット
uspto-grants-2003_09
特許番号
US06613917B1

反応ノート

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