Acetic Acid → 2,3-Difluoro-4-hydroxybenzoic acid
反応式
[F:1][C:2]1[C:7]([F:8])=C(C#N)[CH:5]=[CH:4][C:3]=1[OH:11].[C:12]([OH:15])(=[O:14])[CH3:13]>O.OS(O)(=O)=O>[F:8][C:7]1[C:2]([F:1])=[C:3]([OH:11])[CH:4]=[CH:5][C:13]=1[C:12]([OH:15])=[O:14]参加物
5
実験手順
A mixture of 2,3-difluoro-4-cyanophenol (1 g, 6.45 mmol) in water (8 mL), H2SO4 (8 mL), and acetic acid (8 mL) was refluxed for 48 hours. The solvents were removed by rotary evaporation to give a slurry which was poured onto ice. The product precipitated out of solution and filtered. The solid was washed with water and dried to give 2,3-difluoro-4-hydroxybenzoic acid (800 mg, 71%).
後処理
- temperaturewas refluxed for 48 hours
- customThe solvents were removed by rotary evaporation
- customto give a slurry which
- additionwas poured onto ice
- customThe product precipitated out of solution
- filtrationfiltered
- washThe solid was washed with water
- customdried
出典と根拠
- ORDレコード
- ord-6073920baf8d42518caede8960c366b4
- 出典データセット
- uspto-grants-2003_09
- 特許番号
- US06613942B1
反応ノート
読み込み中…