化工社化工社 化学情報印刷レポート · 研究参考用
4-(Trifluoromethyl)phenylboronic acid → N-{5-[4-(trifluoromethyl)phenyl]thiophene-2-sulfonyl}pyrrole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| 反応物 | N-(5-bromothiophenesulfonyl)pyrrole | HCID 23445587 | — |
| 生成物 | N-{5-[4-(trifluoromethyl)phenyl]thiophene-2-sulfonyl}pyrrole | HCID 22998451 | 75% |
反応手順
N-{5-[4-(trifluoromethyl)phenyl]thiophene-2-sulfonyl}pyrrole was prepared in the same manner as described in Example 32C using 4-trifluoromethylbenzene boronic acid and N-(5-bromothiophene sulfonyl)pyrrole. Purification by column chromatography using 2% ethyl acetate/hexanes gave the pure sulfonamide as a white powder in 75% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06613804B2 |
| 出典データセット | uspto-grants-2003_09 |
| ORD ID | ord-af24c1913aad43beb8e8e3ca1c23881f |
| 出典メモ | uspto-grants-2003_09 |