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Cyclohexene → N-(Piperidin-4-yl)-4'-(trifluoromethyl)-biphenyl-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclohexene | HCID 8079 | — |
| 反応物 | 1-Benzyl-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)piperidine | HCID 22995692 | — |
| 触媒 | Palladium hydroxide | HCID 9942167 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N-(Piperidin-4-yl)-4'-(trifluoromethyl)-biphenyl-2-carboxamide | HCID 9928271 | — |
反応手順
31.6 g (0.072 mol) of 4′-trifluoromethyl-biphenyl-2-carboxylic acid-(1-benzyl-piperidin-4-yl)-amide are dissolved in 180 ml ethanol and 180 ml methanol, mixed with 84 ml (0.83 mol) of cyclohexene and 6.53 g of palladium hydroxide (20% on charcoal) and refluxed for four hours. The hot reaction mixture is filtered through kieselguhr and the reaction mixture is concentrated by rotary evaporation.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06617325B1 |
| 出典データセット | uspto-grants-2003_09 |
| ORD ID | ord-106d94eed4db4e3c9eaca0aec285400e |
| 出典メモ | uspto-grants-2003_09 |