Methyl 2-methyl-2-phenyl-5-{4-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylate → 2-Methyl-2-phenyl-5-{4-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylic acid

HRID 1167108

反応式

HRID 1167108 の反応式
[CH3:1][C:2]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)([CH2:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][CH:14]([NH:17][C:18]([C:20]2[C:21]([C:26]3[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=3)=[CH:22][CH:23]=[CH:24][CH:25]=2)=[O:19])[CH2:13][CH2:12]1)[CH2:3][C:4]([O:6]C)=[O:5]>Cl>[CH3:1][C:2]([C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)([CH2:8][CH2:9][CH2:10][N:11]1[CH2:12][CH2:13][CH:14]([NH:17][C:18]([C:20]2[C:21]([C:26]3[CH:27]=[CH:28][C:29]([C:32]([F:33])([F:34])[F:35])=[CH:30][CH:31]=3)=[CH:22][CH:23]=[CH:24][CH:25]=2)=[O:19])[CH2:15][CH2:16]1)[CH2:3][C:4]([OH:6])=[O:5]

参加物

3

反応物 1

HCID 22995529Methyl 2-methyl-2-phenyl-5-{4-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylate

生成物 1

HCID 229956572-Methyl-2-phenyl-5-{4-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylic acid

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A suspension of 1.5 g (0.0027 mol) of methyl 2-methyl-2-phenyl-5-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylate in 60 ml of 6N hydrochloric acid is refluxed for 25 hours. After cooling the precipitate is filtered off and washed with water and ethyl acetate.

後処理

  1. temperatureis refluxed for 25 hours
  2. temperatureAfter cooling the precipitate
  3. filtrationis filtered off
  4. washwashed with water and ethyl acetate

出典と根拠

ORDレコード
ord-de572782bbc54cb987698d8e06304563
出典データセット
uspto-grants-2003_09
特許番号
US06617325B1

関連ノート

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