Hydrochloric Acid → Ethyl 4-chloro-2-ethoxy-benzimidate hydrochloride

HRID 1167299

反応式

HRID 1167299 の反応式
Cl.[Cl:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[C:5]([O:11][CH2:12][CH3:13])[CH:4]=1.[CH2:14]([OH:16])[CH3:15]>>[ClH:2].[Cl:2][C:3]1[CH:10]=[CH:9][C:6]([C:7](=[NH:8])[O:16][CH2:14][CH3:15])=[C:5]([O:11][CH2:12][CH3:13])[CH:4]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 227211894-Chloro-2-ethoxybenzonitrile2 回

生成物 1

HCID 22996239Ethyl 4-chloro-2-ethoxy-benzimidate hydrochloride収率 94%

反応条件

温度
0 °C

実験手順

Hydrogen chloride gas was passed through a solution of 4-chloro-2-ethoxy-benzonitrile (670 mg, 3.689 mmol) in anhydrous ethanol (25 mL) cooled to 0° C. After 45 min, the hydrogen chloride gas was stopped and the reaction vessel was sealed with a Teflon stopper. It was stirred at room temperature for 5 d. The reaction vessel was cooled to 0° C. and the stopper was removed. The solvent was removed and the residue was triturated in diethyl ether to afford ethyl 4-chloro-2-ethoxy-benzimidate hydrochloride (913 mg, 94%). It was used without further purification.

後処理

  1. temperatureThe reaction vessel was cooled to 0° C.
  2. customthe stopper was removed
  3. customThe solvent was removed
  4. customthe residue was triturated in diethyl ether

出典と根拠

ORDレコード
ord-2d3b6a1461914dc486337f5e277cdc85
出典データセット
uspto-grants-2003_09
特許番号
US06617346B1

関連ノート

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