Hydrochloric Acid → Ethyl 2-(2-dimethylamino-ethoxy)-4-methoxy-benzimidate hydrochloride

HRID 1167313ノート

反応式

HRID 1167313 の反応式
[ClH:1].[CH3:2][N:3]([CH3:17])[CH2:4][CH2:5][O:6][C:7]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:8]=1[C:9]#[N:10].[CH2:18]([OH:20])[CH3:19]>>[ClH:1].[CH3:2][N:3]([CH3:17])[CH2:4][CH2:5][O:6][C:7]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:8]=1[C:9](=[NH:10])[O:20][CH2:18][CH3:19]

参加物

4

反応物 3

HCID 313Hydrochloric Acid2 回HCID 702EthanolHCID 229961862-(2-Dimethylamino-ethoxy)-4-methoxy-benzonitrile

生成物 1

HCID 22996253Ethyl 2-(2-dimethylamino-ethoxy)-4-methoxy-benzimidate hydrochloride収率 96%

実験手順

Hydrogen chloride gas was passed through a solution of 2-(2-dimethylamino-ethoxy)-4-methoxy-benzonitrile (200 mg, 0.908 mmol) in anhydrous ethanol (10 mL) at 0° C. After 45 min, hydrogen chloride gas was stopped and the reaction vessel was sealed with a septum. After stirring at room temperature for 3 d, the reaction vessel was cooled to 0° C. and the septum was removed. The solvent was removed in vacuo to afford ethyl 2-(2-dimethylamino-ethoxy)-4-methoxy-benzimidate hydrochloride as a pale-yellow foam (310 mg, 96%). It was used without further purification.

後処理

  1. customthe reaction vessel was sealed with a septum
  2. temperaturethe reaction vessel was cooled to 0° C.
  3. customthe septum was removed
  4. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-8bc3f7b5c9f24227b5860e0d847c807e
出典データセット
uspto-grants-2003_09
特許番号
US06617346B1

反応ノート

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