Potassium Carbonate → HCID 53857759、化合物

HRID 1167364ノート

反応式

HRID 1167364 の反応式
[CH2:1]([N:8]1[CH:12]=[C:11](O)[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:20]1[O:22][C@@H:21]1[CH2:23]OS(C1C=C([N+]([O-])=O)C=CC=1)(=O)=O>>[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:23][C@@H:21]2[O:22][CH2:20]2)[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 11430Potassium CarbonateHCID 146490Benzenesulfonic acid, 3-nitro-, (2S)-2-oxiranylmethyl esterHCID 6422181-benzyl-1H-pyrazol-4-ol

生成物 1

HCID 53857759HCID 53857759、化合物収率 73.1%

実験手順

1-Benzyl-4-hydroxypyrazoLe (2 g, 11.5 mmol), potassium carbonate(3.2 g, 23 mmol), and (2s)-glycidyl-3-nitrobenzenesulfonate (2.98 g, 11.5 mmol) were slurried in actone (300 ml) at reflux for 17 hours. The acetone was removed in vacuo, the residue extracted from brine with chloroform, and dried over sodium sulfate. The solvent was removed again and the residue purified by column chromatography (silica gel, chloroform→1% methanol/chloroform) to yield product (1.8 g, 68%). MS, NMR.

後処理

  1. temperatureat reflux for 17 hours
  2. customThe acetone was removed in vacuo
  3. extractionthe residue extracted from brine with chloroform
  4. dry with materialdried over sodium sulfate
  5. customThe solvent was removed again
  6. customthe residue purified by column chromatography (silica gel, chloroform→1% methanol/chloroform)

出典と根拠

ORDレコード
ord-cb4df2da71a3482199397b94f6a5dc69
出典データセット
uspto-grants-2003_09
特許番号
US06617347B1

反応ノート

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