Bromine → 2-Bromo-1-(4-methoxyphenyl)-2-(3-pyridyl)ethanone hydrobromide

HRID 1167647

反応式

HRID 1167647 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:17])[CH2:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[CH:5][CH:4]=1.[Br:18]Br>C(O)(=O)C>[BrH:18].[Br:18][CH:10]([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[C:9]([C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=1)=[O:17]

参加物

4

反応物 2

HCID 24408BromineHCID 2383511-(4-Methoxyphenyl)-2-(pyridin-3-yl)ethanone

生成物 1

HCID 114633362-Bromo-1-(4-methoxyphenyl)-2-(3-pyridyl)ethanone hydrobromide収率 89%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
80 °C

実験手順

1-(4-Methoxyphenyl)-2-(3-pyridyl)ethanone (6.85 g) was dissolved in acetic acid (36 mL), bromine (1.7 mL) was added to the solution and the resulting mixture was stirred at 80° C. for 3 h. After the mixture was cooled with ice-water, the crude crystalline mass was collected by filtration. The crude crystalline was recrystallized from ethanol-ethyl ether to afford the title compound (10.4 g, yield 89%).

後処理

  1. filtrationthe crude crystalline mass was collected by filtration
  2. customThe crude crystalline was recrystallized from ethanol-ethyl ether

出典と根拠

ORDレコード
ord-aca100503a0f485b965d3e860002da0a
出典データセット
uspto-grants-2003_09
特許番号
US06620825B1

関連ノート

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